Over the past 21 years, Dr. Rock has developed and conducted numerous clinical studies focused on understanding the associations between nutritional factors and risk and progression of chronic disease, biomarkers and risk factors. Dr. Rock has served as PI for several diet and weight loss interventions and clinical trials focused on the role of nutritional factors, diet, and obesity in the development and progression of cancer. She currently leads the Nutrition Shared Resource at the Moores UC San Diego Cancer Center, a recharge laboratory unit that conducts dietary assessments and quantitative biochemical analysis of dietary biomarkers and other factors in biological samples. Dietary biomarker studies that Dr. Rock has initiated or with which she has been involved have focused on carotenoids, vitamin D, folate, curcumin, polyamines and lipids.
- The role of nutritional factors (diet and obesity) in the risk and progression of cancer
- Healthy weight management and the treatment of obesity
- Effects of diet composition on metabolic and disease risk factors
- Dietary biomarkers
- Influence of nutritional factors on hormones, especially reproductive hormones, and hormonal status
- Bioactive food components, including carotenoids, curcumin, and polyamines
- Rock CL, Gorenflo DW, Drewnowski A, Demitrack MA. Nutritional characteristics, eating pathology, and hormonal status in young women. American Journal of Clinical Nutrition 64:566-571, 1996.
- Rock CL, Lovalvo JL, Emenhiser C, Ruffin MT, Flatt SW, Schwartz SJ. Bioavailability of beta-carotene is lower in raw than in processed carrots and spinach in women. Journal of Nutrition 128:913-916, 1998.
- Rock CL, Moskowitz A, Huizar B, Saenz CC, Clark JT, Daly TL, Chin H, Behling C, Ruffin MT. High vegetable and fruit diet intervention in premenopausal women with cervical intraepithelial neoplasia. Journal of the American Dietetic Association 101:1167-1174, 2001.
- Rock CL, Demark-Wahnefried W. Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. Journal of Clinical Oncology 20:3302-3316, 2002.
- Rock CL, Flatt SW, Thomson C, Stefanick ML, Newman VA, Jones L, Natarajan L, Pierce JP, Chang RJ, Witztum JL. Plasma triacylglycerol and HDL cholesterol concentrations confirm self-reported changes in carbohydrate and fat intakes in women in a diet intervention trial. Journal of Nutrition 134:342-347, 2004.
- Rock CL, Flatt SW, Thomson CA, Stefanick ML, Newman VA, Jones L, Natarajan L, Ritenbaugh C, Hollenbach KA, Pierce JP, Chang RJ. Effects of high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer. Journal of Clinical Oncology 22:2379-2387, 2004.
- Zoumas-Morse C, Rock CL, Quintana E, Neuhouser ML, Gerner EW, Meyskens FL. Development of a polyamine database for assessing dietary intake. Journal of the American Dietetic Association 107:1024-1027, 2007.
- Rock CL, Flatt SW, Laughlin GA, Gold EB, Thomson CA, Natarajan L, Jones LA, Caan BJ, Stefanick ML, Hajek RA, Al-Delaimy K, Stanczyk FZ, Pierce JP. Reproductive steroid hormones and recurrence-free survival in women with a history of breast cancer. Cancer Epidemiology Biomarkers & Prevention 17:614-620, 2008.
- Rock CL, Natarajan L, Pu M, Thomson CA, Flatt SW, Caan BJ, Gold EB, Al-Delaimy WD, Newman VA, Stefanick ML, Pierce JP. Longitudinal biological exposure to carotenoids is associated with breast cancer-free survival in the Women’s Healthy Eating and Living Study. Cancer Epidemiology Biomarkers & Prevention 18:486-494, 2009.
- Rock CL, Flatt SW, Sherwood NE, Karanja N, Pakiz B, Thomson CA. Effect of a free prepared meal and incentivized weight loss program on weight loss and weight loss maintenance in obese and overweight women: a randomized controlled trial. Journal of the American Medical Association 304:1803-1811, 2010.